The documented causes: license, payment, backorder
Empower Pharmacy's FAQ is specific about why the portal blocks orders: 'Some of the reasons you may be experiencing issues with placing an order through your portal are: one of your licenses is expired, your credit card is not going through, or the product you are trying to order is on backorder.' These three causes cover most order failures, and two of them — an expired license and a credit card — are knowable in advance of submitting a specific order.
The resolution path for all three is the same: call (877) 562-8577 during Mon-Fri 7:00 AM-7:00 PM CT to speak with a clinic liaison. That is the correct path — Empower Pharmacy's support is available and documented. But the cost is timing: the block appears when you are trying to process an order, not in a pre-flight check, which means the order is already built and the patient is already waiting when the problem surfaces.